The Czech Republic is much more than the dálnice that links Prague to the rest of the country. The Czech Republic's highlights range from Prague's medieval old town to picturesque castles, a 138-metre-deep gorge and one of the world's most famous breweries, and they're all easy to combine on a road trip. Some lie right next to the motorway, others are worth a short, easily manageable detour.
The D1 links Prague with Brno and Ostrava, the D5 runs to Plzeň and the German border, and the D8 to Dresden. But the Czech Republic's finest spots are by no means all located along those motorways. The selection below combines vignette-required main routes with destinations that are easy to reach by car, even if that means a shorter or longer detour.

Prague Castle, Charles Bridge and the astronomical clock on Old Town Square: one of Europe's best-preserved historic city centres, largely untouched by the world wars. UNESCO World Heritage Site.

After Prague, the country's biggest tourist draw: a medieval town with winding cobbled streets wrapped around one of Europe's largest castles, embraced by a loop of the Vltava river. UNESCO World Heritage Site.

A spectacular karst region featuring the 138-metre-deep Macocha Gorge and the Punkva Caves, where a boat carries you along an underground river to the bottom of the gorge.

The birthplace of pilsner beer: here, in 1842, the clear bottom-fermented beer that would later become known worldwide as "pils" was brewed for the first time. The brewery can be visited, historic cellars included.

An atmospheric spa town with colourful belle-époque façades lining the Teplá river, famous for its hot springs and its annual international film festival. UNESCO World Heritage Site since 2021, as part of the "Great Spa Towns of Europe".

A medieval silver-mining town home to the striking St Barbara's Church, one of Central Europe's finest Gothic churches, and the famous Sedlec "bone church", decorated with the bones of tens of thousands of people. UNESCO World Heritage Site.
This selection is a starting point. Combine it with the prices and validity periods of the Czech vignette to complete your route.